An Aviva Stadium crowd of 40,156 watched Joe Schmidt's much-changed side score six tries in the second half, including a brace from fullback Felix Jones and one from Ulster centre Stuart Olding, to continue their winning start to new international season.
Three penalties from the boot of Ian Madigan had Ireland leading 9-0 at half time, the last of them coming after Georgia scrum half Giorgi Begadze was yellow carded for not rolling away.
Ireland punished the 14-man Lelos with an early try on the resumption from lively prop Dave Kilcoyne and his front row colleague Richardt Strauss dived over from a lineout maul in the 51st minute.
Madigan converted scores both but Georgia, restored to their full complement, hit back when Begadze released lock Giorgi Nemsadze for a well-taken try approaching the hour.
However, Ireland bossed the final quarter to score 26 points without reply - 19 of them coming while Georgian number 8 Dimitri Basilaia was in the sin-bin.
The tiring tourists were caught for numbers on the left as Darren Cave and Madigan combined to put winger Simon Zebo over in the 62nd minute. The Irish bench was unloaded with Stuart Olding passing for Jones to touch down in the right corner, six minutes later.
Robin Copeland, who joined fellow debutants Dave Foley and Dominic Ryan on the pitch, forced the turnover which led to the best try of the game. Kieran Marmion countered from deep and linked with fellow replacements Ian Keatley and Sean Cronin who set up Jones to come in off the left wing, beat the final defender and complete his brace.
Madigan missed the conversion but duly took his haul to 19 points when adding the extras to Olding's first try for Ireland, which saw him dart away and in behind the posts after a lovely midfield switch with Keatley.
So, numbers wise it was a very good day at the office for Ireland - there were three debutants with one of them, second row Foley, winning the man-of-the-match award, and three players scored their first Test tries (Kilcoyne, Jones and Olding).
Overall, eight players in the squad made their Aviva Stadium debuts and Ireland ended up posting their highest score and biggest winning margin at home since November 2008's 55-0 defeat of Canada at Thomond Park.
Performance-wise, there were some holes which the coaches and players will look at, but that free-scoring final quarter keeps the momentum going heading in next Saturday's Guinness Series finale against Australia.