The 10th placed finisher in each division is automatically relegated while the ninth placed team in each division will end up in a promotion/relegation playoff semi-final.
Division 1A
Ulster's only top-flight representatives Ballynahinch will finish the season in either 5th or 6th place. They're currently in 5th, and sit 3 points ahead of Saturday's opponents Lansdowne, who occupy 6th place. Clontarf only need 1 point against UCD to finish on top of the table.
Division 1B
City of Armagh will travel to Buccaneers having already secured promotion and the title, as they sit 7 points clear of Old Belvedere.
However, It’s high-stakes stuff at the Mardyke – Malone (10th) need a win there to have any chance of a great escape while a win for UCC (8th) will ensure they avoid back-to-back relegations.
Banbridge (9th) are caught between a rock and a hard place, given they can overtake UCC but also still be caught by Malone. Home advantage at Rifle Park will be vital against promotion chasing Highfield (3rd).
Division 2A
The top four teams have already earned their shot at promotion, while the order of their final placings is still to be confirmed.
Dolphin host Queen’s University (1st) who will be desperate to avoid any final round drama and ensure automatic promotion. Blackrock College (2nd) are two points behind the leaders and away to Ballymena (7th).
Division 2B
Greystones (1st) will lift the Division 2B trophy this weekend against an Enniscorthy (10th) side hoping to avoid automatic relegation. ‘Scorthy are a point behind Galwegians (9th) who are at home to a Dungannon (3rd) side guaranteed their promotion play-off spot.
Galway Corinthians (2nd) will finish as runners-up in the table but there are four teams chasing the last promotion play-off spot.
Sligo (4th) have 43 points with Wanderers (5th), Belfast Harlequins (6th) and Rainey Old Boys (7th) all on 42 points.
Sligo host Belfast Harlequins with Wanderers away to Malahide (8th) and Rainey at home to Corinthians.
Division 2C
Instonians (1st) may have already been promoted and presented with their Division 2C trophy but they’ll be aware of the chance to record a perfect season on the league table – the Belfast men will finish with 90 points from a possible 90 if they can bag four tries and a win against Tullamore.
Bangor (6th), Ballina and Omagh Academicals (8th) can all be pulled into the promotion/relegation play-off spot currently occupied by Midleton (9th).
Bangor travel to relegated Sunday's Well, with Omagh home to Bruff, who can still make the promotion playoffs.