Sean Reffell sustained a shoulder injury in Round 4's victory over Hollywoodbets Sharks and he will consequently be unavailable for selection for a number of weeks.
Juarno Augustus suffered an arm injury, and his fitness will be monitored through training this week.
Iain Henderson, Jacob Stockdale, Nick Timoney and Stuart McCloskey have all left the squad to link up with the Ireland national team ahead of the upcoming November matches.
Marcus Rea, Ben Carson, Charlie Irvine and Bryn Ward have been added to the squad.