Rory Best, Chris Henry and Andrew Trimble will start for Ireland against England in an unchanged side for the team that beat Wales a fortnight ago.
Rory Best will become Ulster’s most capped Ireland international, overtaking David Humphreys’ record of 72 appearances.
Iain Henderson has been named on the bench in place of the injured Dan Tuohy, with Paddy Jackson completing the Ulster representation.
Paul O'Connell will lead the side as Ireland seek their first win in Twickenham since 2010.
Brian O'Driscoll will equal George Gregan as the most capped player of all time in Test rugby.
Leinster’s Jordi Murphy will make his first international appearance if called upon.
IRELAND Team & Replacements v England, Twickenham Stadium, London,
RBS 6 Nations Championship, Saturday 22nd February kick-off 16.00 GMT
Player/Club/Province/Caps
15. Rob Kearney (UCD/Leinster) 51
14. Andrew Trimble (Ballymena/Ulster) 52
13. Brian O'Driscoll (UCD/Leinster) 130
12. Gordon D'Arcy (Lansdowne/Leinster) 76
11. Dave Kearney (Lansdowne/Leinster) 4
10. Jonathan Sexton (Racing Metro 92) 40
9. Conor Murray (Garryowen/Munster) 24
8. Jamie Heaslip (Dublin University/Leinster) 62
7. Chris Henry (Malone/Ulster) 11
6. Peter O'Mahony (Cork Constitution/Munster) 21
5. Paul O'Connell (Young Munster/Munster) 89 capt
4. Devin Toner (Lansdowne/Leinster) 12
3. Mike Ross (Clontarf/Leinster) 36
2. Rory Best (Banbridge/Ulster) 72
1. Cian Healy (Clontarf/Leinster) 44