Gilroy has failed to recover from a groin strain and is replaced by Fergus McFadden, while Fitzpatrick has a calf strain.
An opening has been left in the match 23 for the starting and replacement flyhalf positions as Paddy Jackson has a tight hamstring which is being monitored. Leinster's Jonathan Sexton has also continued his rehabilitation programme on his hamstring injury and a decision on both positions will be made later in the week.
There are three confirmed changes from the last outing, with Mike McCarthy and Cian Healy coming into the forwards in place of Donncha O'Callaghan and Tom Court respectively.
The Ireland Team to play France on Saturday 9th March 2013 in Aviva Stadium, Dublin in the RBS 6 Nations Championship, K.O. 5:00 pm, is: (Player/club/province/international caps):
15 - Rob Kearney (UCD/Leinster/44)
14 - Fergus McFadden (Old Belvedere/Leinster/16)
13 - Brian O'Driscoll (UCD/Leinster/123)
12 - Luke Marshall (Ballymena/Ulster/1)
11 - Keith Earls (Young Munster/Munster/37)
10 - A.N. Other
9 - Conor Murray (Garryowen/Munster/17)
1 - Cian Healy (Clontarf/Leinster/37)
2 - Rory Best (Banbridge/Ulster/65)
3 - Mike Ross (Clontarf/Leinster/27)
4 - Mike McCarthy (Buccaneers/Connacht/8)
5 - Donnacha Ryan (Shannon/Munster/26)
6 - Peter O'Mahony (Cork Constitution/Munster/12)
7 - Sean O'Brien (UCD/Leinster/25)
8 - Jamie Heaslip (Dublin University/Leinster/55) Captain
Replacements: 16 - Sean Cronin (St. Mary's College/Leinster/24)
17 - David Kilcoyne (UL Bohemians/Munster/5)
18 - A.N. Other
19 - Donncha O'Callaghan (Cork Constitution/Munster/93)
20 - Iain Henderson (Ballynahinch/Ulster/3)
21 - Eoin Reddan (Lansdowne/Leinster/49)
22 - A.N. Other
23 - Luke Fitzgerald (Blackrock College /Leinster/24)