The fixture will take place on Sunday, 23 February and kick off at 1pm.
The most recent meeting between the teams was back in 2015 – then named England Saxons and Ireland Wolfhounds – and saw the visitors claim a 18-9 victory at Musgrave Park in Cork.
IRFU Performance Director, David Humphreys, said: “We’re delighted to add this Ireland ‘A’ fixture to next season’s schedule, once again providing a broader pool of players with further exposure to the National Team environment.
“Access to meaningful and consistent game time for our emerging players is a key focus and this match will come off the back of our Emerging Ireland Tour to South Africa this Autumn and a busy November schedule for our Men’s Senior team.”
Broadcast information will be confirmed in due course, while tickets can be purchased via England Rugby here.