Johnny Sexton returns to the starting XV and will captains the side from out-half. Jamison Gibson Park is named alongside him at halfback.
Bundee Aki is restored to the midfield to partner Garry Ringrose while Andrew Conway and Hugo Keenan come back into the backfield alongside James Lowe who is retained from the Italy game.
Cian Healy wins his 115th cap in a front row that also includes Dan Sheehan and Tadhg Furlong.
Tadhg Beirne and James Ryan line out in the engine room while Peter O’Mahony, Josh van der Flier and Caelan Doris make up the backrow.
In the replacements , Rob Herring, Dave Kilcoyne, Finlay Bealham, Iain Henderson and Jack Conan cover the pack. Conor Murray, Joey Carbery and Robbie Henshaw are the backline replacements.
The game which kicks off at 4.45pm will be televised by ITV (NI) and RTE (ROI). Both sides require a victory to maintain their Championship ambitions
Ireland Team & Replacements (v England, 2022 Guinness Six Nations, Twickenham, Saturday, 12 March, kick-off 4.45pm):
15\. Hugo Keenan (Leinster/UCD) 18 caps
14\. Andrew Conway (Munster/Garryowen) 29 caps
13\. Garry Ringrose (Leinster/UCD) 40 caps
12\. Bundee Aki (Connacht/Galwegians) 35 caps
11\. James Lowe (Leinster) 10 caps
10\. Johnny Sexton (Leinster/St Mary’s College) 103 caps CAPTAIN
9\. Jamison Gibson Park (Leinster) 15 caps
1\. Cian Healy (Leinster/Clontarf) 114 caps
2\. Dan Sheehan (Leinster/Lansdowne) 5 caps
3\. Tadhg Furlong (Leinster/Clontarf) 55 caps
4\. Tadhg Beirne (Munster/Lansdowne) 28 caps
5\. James Ryan (Leinster/UCD) 42 caps
6\. Peter O’Mahony (Munster/Cork Constitution) 82 caps
7\. Josh van der Flier (Leinster/UCD) 38 caps
8\. Caelan Doris (Leinster/St Mary’s College) 15 caps
Replacements
16. Rob Herring (Ulster/Ballynahinch) 24 caps
17\. Dave Kilcoyne (Munster/UL Bohemians) 46 caps
18\. Finlay Bealham (Connacht/Buccaneers) 21 caps
19. Iain Henderson (Ulster/Academy) 66 caps
20\. Jack Conan (Leinster/Old Belvedere) 25 caps
21\. Conor Murray (Munster/Garryowen) 94 caps
22\. Joey Carbery (Munster/Clontarf) 30 caps
23\. Robbie Henshaw (Leinster/Buccaneers) 55 caps