This game will be Ulster's final regular season home fixture, and will be potentially critical in the race to the URC playoffs.
This will be the Sharks' first visit to Belfast, having joined the URC ahead of this season, and they are currently the highest placed team of the four new South African franchises.
The Sharks squad features a host of international talent, including 2019 South Africa World Cup winning captain Siya Kolisi and his fellow Springbok stars Lukhanyo Am, Makazole Mapimpi and Sbu Nkosi among others.
Ulster's Remaining URC Fixtures:
Round 14: Sat 26 Mar, 1pm<br>
DHL Stormers v Ulster Rugby
Round 15: Sat 2 Apr, 1pm<br>
Vodacom Bulls v Ulster Rugby
Round 16: Fri 22 Apr, 7.35pm<br>
Ulster Rugby v Munster Rugby<br>
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Round 17: Sat 30 Apr, 7.35pm<br>
Edinburgh Rugby v Ulster Rugby
Round 18: Fri 20 May, 7.35pm<br>
Ulster Rugby v Cell C Sharks<br>
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All kick-off times shown in UK / Ire time.
United Rugby Championship Playoffs:
After 18 rounds of games, the top eight teams will qualify for the Quarter-Finals, followed by Semi-Finals and a Final. Teams will be seeded from 1 to 8 and will receive home advantage according to their seeding for these fixtures.
URC Quarter Finals: 3/4/5 June
URC Semi-Finals: 10/11/12 June
URC Final: 23/24/25 June