James Hume suffered a back injury during the recent Investec Champions cup defeat against Union Bordeaux Begles.
He is currently unavailable for selection and joins Iain Henderson (hamstring), Jake Flannery (knee), Ethan McIlroy (knee), Rob Baloucoune (hamstring), Ben Carson (neck), Ben Moxham (knee), Eric O'Sullivan (knee) and Sean Reffell (calf) on the current injured players' list.
Cormac Izuchukwu (ankle), Werner Kok (hamstring) and Jude Postlethwaite have all recovered from their respective recent injuries and are available for selection.