Joe Schmidt has named Paddy Jackson, Luke Marshall and Craig Gilroy in his starting team for Ireland's game against Canada at the Aviva Stadium on Saturday evening (7.15pm).
Peter O'Mahony will captain the side in what will be his first outing in a green shirt since the 2015 Rugby World Cup.
There are 3 uncapped players in the starting XV and a further 5 named in the replacements.
O'Mahony is joined in the back row by Sean O'Brien and the uncapped Jack O'Donoghue. Billy Holland will make his Ireland debut in the second row alongside Ultan Dillane while last weekend's replacement front row of Finlay Bealham, Sean Cronin and Cian Healy start this weekend.
Kieran Marmion and Jackson form a partnership at half-back, while Marshall and new cap Garry Ringrose are paired together in the midfield.
The back-three is made up of Gilroy and Keith Earls on the wings and Tiernan O'Halloran, capped during the summer in South Africa, at fullback.
In the replacements, the five uncapped players are James Tracy, John Ryan, Dan Leavy, Luke McGrath and Niyi Adeolokun.
They are joined by Dave Kilcoyne, Donnacha Ryan and Joey Carbery, who made his debut against New Zealand in Chicago.
IRELAND team and replacements (v Canada, Guinness Series, Aviva Stadium, Saturday 12th November, 2016, 7.15pm):
15. Tiernan O'Halloran (Buccaneers / Connacht)
14. Craig Gilroy (Bangor / Ulster)
13. Garry Ringrose (UCD / Leinster)*
12. Luke Marshall (Ballymena / Ulster)
11. Keith Earls (Young Munster / Munster)
10. Paddy Jackson (Dungannon / Ulster)
9. Kieran Marmion (Corinthians / Connacht)
1. Cian Healy (Clontarf / Leinster)
2. Sean Cronin (St. Mary's College / Leinster)
3. Finlay Bealham (Buccaneers / Connacht)
4. Ultan Dillane (Corinthians / Connacht)
5. Billy Holland (Cork Constitution / Munster)*
6. Peter O'Mahony (Cork Constitution / Munster) captain
7. Sean O'Brien (UCD / Leinster)
8. Jack O'Donoghue (UL Bohemians / Munster)*
Replacements:
16. James Tracy (UCD / Leinster)*
17. Dave Kilcoyne (UL Bohemians / Munster)
18. John Ryan (Cork Constitution / Munster)*
19. Donnacha Ryan (Shannon / Munster)
20. Dan Leavy (UCD / Leinster)*
21. Luke McGrath (UCD / Leinster)*
22. Joey Carbery (Clontarf / Leinster)
23. Niyi Adeolokun (Galwegians / Connacht) *
*denotes uncapped player
Peter O'Mahony will captain the side in what will be his first outing in a green shirt since the 2015 Rugby World Cup.
There are 3 uncapped players in the starting XV and a further 5 named in the replacements.
O'Mahony is joined in the back row by Sean O'Brien and the uncapped Jack O'Donoghue. Billy Holland will make his Ireland debut in the second row alongside Ultan Dillane while last weekend's replacement front row of Finlay Bealham, Sean Cronin and Cian Healy start this weekend.
Kieran Marmion and Jackson form a partnership at half-back, while Marshall and new cap Garry Ringrose are paired together in the midfield.
The back-three is made up of Gilroy and Keith Earls on the wings and Tiernan O'Halloran, capped during the summer in South Africa, at fullback.
In the replacements, the five uncapped players are James Tracy, John Ryan, Dan Leavy, Luke McGrath and Niyi Adeolokun.
They are joined by Dave Kilcoyne, Donnacha Ryan and Joey Carbery, who made his debut against New Zealand in Chicago.
IRELAND team and replacements (v Canada, Guinness Series, Aviva Stadium, Saturday 12th November, 2016, 7.15pm):
15. Tiernan O'Halloran (Buccaneers / Connacht)
14. Craig Gilroy (Bangor / Ulster)
13. Garry Ringrose (UCD / Leinster)*
12. Luke Marshall (Ballymena / Ulster)
11. Keith Earls (Young Munster / Munster)
10. Paddy Jackson (Dungannon / Ulster)
9. Kieran Marmion (Corinthians / Connacht)
1. Cian Healy (Clontarf / Leinster)
2. Sean Cronin (St. Mary's College / Leinster)
3. Finlay Bealham (Buccaneers / Connacht)
4. Ultan Dillane (Corinthians / Connacht)
5. Billy Holland (Cork Constitution / Munster)*
6. Peter O'Mahony (Cork Constitution / Munster) captain
7. Sean O'Brien (UCD / Leinster)
8. Jack O'Donoghue (UL Bohemians / Munster)*
Replacements:
16. James Tracy (UCD / Leinster)*
17. Dave Kilcoyne (UL Bohemians / Munster)
18. John Ryan (Cork Constitution / Munster)*
19. Donnacha Ryan (Shannon / Munster)
20. Dan Leavy (UCD / Leinster)*
21. Luke McGrath (UCD / Leinster)*
22. Joey Carbery (Clontarf / Leinster)
23. Niyi Adeolokun (Galwegians / Connacht) *
*denotes uncapped player