Tommy, who started on the right flank against Western Force on Wednesday, will move to occupy the left wing berth at Suncorp Stadium this weekend.
Tour captain Warburton makes his debut against the Reds, featuring alongside prop Gethin Jenkins, while lock Geoff Parling, prop Matt Stevens, hooker Tom Youngs and his brother, scrum-half Ben Youngs will all make their run-on debuts for the Lions.
Tour Manager Andy Irvine said: "We have played two matches so far and have done very well but the stakes get higher on Saturday against the Reds, who are a leading Super Rugby side. It is the type of game we require at this point in the tour and it will be a measure of how we are progressing on the field.
“Tour captain Sam Warburton is the last of the 2013 tourists that has yet to pull on the famous red jersey. He is now fit and raring to play and it is great that he marks the occasion by becoming the 800th British & Irish Lion.”
Head Coach Warren Gatland said: “Two wins and two victories is great but those two matches are building blocks as we head towards the Test series. We always said we would give every player a start in the first three matches and this team reflects that. It also provides us with the opportunity to continue to look at different combinations.
“For the Reds match this includes a new centre pairing and a different front five. At the same time we have several players playing their second matches on tour and some proven combinations starting the match. Ben Youngs and Owen Farrell are the incumbent England halfbacks and we have an all-Welsh backrow.”
British & Irish Lions Squad to face Queensland Reds, June 8, kick-off 10.30am, Suncorp Stadium, Brisbane.
British & Irish Lions (15-1): Stuart Hogg, Alex Cuthbert, Manu Tuilagi, Jonathan Davies, Tommy Bowe, Owen Farrell, Ben Youngs, Toby Faletau, Sam Warburton (C), Dan Lydiate, Geoff Parling, Richie Gray, Matt Stevens, Tom Youngs, Gethin Jenkins.
Replacements (16-23): Richard Hibbard, Makovina Vunipola, Adam Jones, Paul O’Connell, Justin Tipuric, Conor Murray, Jonathan Sexton, George North.