Ulster club captain Iain Henderson retains his place at lock and Ulster prop Tom O'Toole is named among the replacements.
Ireland captain Johnny Sexton returns to the side to face Scotland this Sunday at BT Murrayfield.
Sexton missed the Round 3 fixture in Rome against Italy having picked up a knock against France in the previous round. Sexton is currently seven points behind the all-time leading Six Nations points scorer, fellow Irishman Ronan O’Gara (557 Six Nations points).
Conor Murray is also restored to the starting line up having impressed off the bench against Italy. In the midfield, Bundee Aki shifts to inside centre with Garry Ringrose returning to the starting line-up. The back three that has started every game of this Championship campaign lines out again with Hugo Keenan at full-back and Mack Hansen and James Lowe on the wings.
Up front, Dan Sheehan and Tadhg Furlong are introduced to the front row to join Andrew Porter.
James Ryan joins Iain Henderson in the second row with Peter O’Mahony starting at blindside flanker, Caelan Doris shifting to number eight and Josh van der Flier lining out at openside.
Cian Healy, Jamison Gibson-Park and Robbie Henshaw are included amongst the replacements alongside Ronan Kelleher, Tom O’Toole, Ryan Baird, Jack Conan and Ross Byrne.
Squad in full
IRELAND team to play Scotland – Round 4, 2023 Guinness Six Nations Championships, BT Murrayfield, Edinburgh, Sunday 12th March, 2023, KO 15.00 (IST):
15\. Hugo Keenan (Leinster/UCD) 28 caps<br>
14\. Mack Hansen (Connacht/Corinthians) 12 caps<br>
13\. Garry Ringrose (Leinster/UCD) 49 caps<br>
12\. Bundee Aki (Connacht/Galwegians) 44 caps<br>
11\. James Lowe (Leinster) 18 caps<br>
10\. Johnny Sexton (Leinster/St Mary’s College) 111 caps (c)<br>
9\. Conor Murray (Munster/Garryowen) 103 caps
1\. Andrew Porter (Leinster/UCD) 51 caps<br>
2\. Dan Sheehan (Leinster/Lansdowne) 15 caps<br>
3\. Tadhg Furlong (Leinster/Clontarf) 63 caps<br>
4\. Iain Henderson (Ulster/Academy) 71 caps<br>
5\. James Ryan (Leinster/UCD) 51 caps<br>
6\. Peter O’Mahony (Munster/Cork Constitution) 92 caps<br>
7\. Josh van der Flier (Leinster/UCD) 48 caps<br>
8\. Caelan Doris (Leinster/St Mary’s College) 26 caps
Replacements:
16\. Ronan Kelleher (Leinster/Lansdowne) 20 caps<br>
17\. Cian Healy (Leinster/Clontarf) 121 caps<br>
18\. Tom O’Toole (Ulster/Ballynahinch) 7 caps<br>
19\. Ryan Baird (Leinster/Dublin University) 9 caps<br>
20\. Jack Conan (Leinster/Old Belvedere) 36 caps<br>
21\. Jamison Gibson Park (Leinster) 23 caps<br>
22\. Ross Byrne (Leinster/UCD) 17 caps<br>
23\. Robbie Henshaw (Leinster/Buccaneers) 61 caps
2023 Guinness Six Nations Fixtures & Results:
Wales 10 IRELAND 34<br>
Principality Stadium, Saturday 4th February 2023
IRELAND 32 France 19<br>
Aviva Stadium, Saturday 11th February 2023
Italy 20 IRELAND 34<br>
Stadio Olimpico, Saturday 25th February 2023
Scotland v IRELAND<br>
Sunday 12th March 2023, KO 15:00 (IST)<br>
RTE TV / BBC / RTE Radio / BBC Radio
IRELAND v England<br>
Saturday 18th March 2023, KO 17:00 (IST)<br>
VIRGIN / ITV / RTE Radio / BBC Radio